Antifungal styryloquinolines as candida albicans efflux pump inhibitors: Styryloquinolines are ABC transporter inhibitors

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Abstract

Styrylquinolines are heterocyclic compounds that are known for their antifungal and antimicrobial activity. Metal complexation through hydroxyl groups has been claimed to be a plausible mechanism of action for these types of compounds. A series of novel structures with protected hydroxyl groups have been designed and synthesized to verify the literature data. Their antifungal activity against wild-type Candida albicans strain and mutants with silenced efflux pumps activity has been determined. Combinations with fluconazole revealed synergistic interactions that were dependent on the substitution pattern. These results open a new route for designing active antifungal agents on a styrylquinoline scaffold.

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Cieslik, W., Szczepaniak, J., Krasowska, A., & Musiol, R. (2020). Antifungal styryloquinolines as candida albicans efflux pump inhibitors: Styryloquinolines are ABC transporter inhibitors. Molecules, 25(2). https://doi.org/10.3390/molecules25020345

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