Clinical recognition of drug-induced vasculitic and lupus-like syndromes is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary haemorrhage). Withdrawal of the drug often leads to spontaneous recovery, meaning that immunosuppressive therapy can be avoided. The presence of myeloperoxidase-antineutrophil cytoplasmic antibodies, IgM anticardiolipin antibody, and antihistone antibodies in combination was found to be characteristic of drug-induced vasculitic syndromes caused by the antithyroid drugs propylthiouracil and methimazol. Clinically, skin vasculitis and arthralgias predominated and renal vasculitis was rare. © 2005 BioMed Central Ltd.
CITATION STYLE
Wiik, A. (2005). Clinical and laboratory characteristics of drug-induced vasculitic syndromes. Arthritis Research and Therapy, 7(5), 191–192. https://doi.org/10.1186/ar1805
Mendeley helps you to discover research relevant for your work.