Effects of short-term quetiapine treatment on emotional processing, sleep and circadian rhythms

14Citations
Citations of this article
95Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Background: Quetiapine is an atypical antipsychotic that can stabilise mood from any index episode of bipolar disorder. This study investigated the effects of seven-day quetiapine administration on sleep, circadian rhythms and emotional processing in healthy volunteers. Methods: Twenty healthy volunteers received 150 mg quetiapine XL for seven nights and 20 matched controls received placebo. Sleep-wake actigraphy was completed for one week both pre-dose and during drug treatment. On Day 8, participants completed emotional processing tasks. Results: Actigraphy revealed that quetiapine treatment increased sleep duration and efficiency, delayed final wake time and had a tendency to reduce within-day variability. There were no effects of quetiapine on subjective ratings of mood or energy. Quetiapine-treated participants showed diminished bias towards positive words and away from negative words during recognition memory. Quetiapine did not significantly affect facial expression recognition, emotional word categorisation, emotion-potentiated startle or emotional word/faces dot-probe vigilance reaction times. Conclusions: These changes in sleep timing and circadian rhythmicity in healthy volunteers may be relevant to quetiapine's therapeutic actions. Effects on emotional processing did not emulate the effects of antidepressants. The effects of quetiapine on sleep and circadian rhythms in patients with bipolar disorder merit further investigation to elucidate its mechanisms of action.

References Powered by Scopus

Development and Validation of Brief Measures of Positive and Negative Affect: The PANAS Scales

30226Citations
N/AReaders
Get full text

LIKABLENESS RATINGS OF 555 PERSONALITY-TRAIT WORDS

1173Citations
N/AReaders
Get full text

Nonparametric indexes for sensitivity and bias: Computing formulas

867Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Brief Mindfulness Meditation Improves Emotion Processing

71Citations
N/AReaders
Get full text

Effects of quetiapine on sleep: A systematic review and meta-analysis of clinical trials

27Citations
N/AReaders
Get full text

Sleep quality and emotional reactivity cluster in bipolar disorders and impact on functioning

21Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Rock, P. L., Goodwin, G. M., Wulff, K., McTavish, S. F. B., & Harmer, C. J. (2016). Effects of short-term quetiapine treatment on emotional processing, sleep and circadian rhythms. Journal of Psychopharmacology, 30(3), 273–282. https://doi.org/10.1177/0269881115626336

Readers over time

‘16‘17‘18‘19‘20‘21‘22‘23‘24‘2508162432

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 28

56%

Researcher 14

28%

Professor / Associate Prof. 4

8%

Lecturer / Post doc 4

8%

Readers' Discipline

Tooltip

Psychology 24

41%

Medicine and Dentistry 21

36%

Nursing and Health Professions 7

12%

Neuroscience 7

12%

Save time finding and organizing research with Mendeley

Sign up for free
0