2,5-Disubstituted 1,3,4-oxadiazole derivatives of chromeno[4,3-b]pyridine: Synthesis and study of antimicrobial potency

Abstract

A convenient synthesis of 1,3,4-oxadiazole containing derivatives of chromeno[4,3-b]pyridine (6a-e, 8a-e and 9a-e) starting from 4-hydroxycoumarin is presented. The synthesized compounds were screened for in vitro antimicrobial activity against representative bacterial and fungal species. The MIC (minimum inhibitory concentration) of the synthesized compounds ranges between 5 and 15 μg/mL, which is comparable with MIC of standard drugs. Compounds 6c, 8c-e, 9c and 9e have the highest potency for certain bacteria and fungi.