Abstract
Novel podophyllotoxin xyloside derivatives 8 to 11 were synthesized and evaluated for their cytotoxicities against a panel of 5 human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using [3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays. These derivatives showed good to moderate activities, with compound 9 having an IC50 value of 4.42 μM against the A-549 cell line. Overall, compound 9 might be a promising candidate for further development.
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Zi, C. T., Yang, L., Zhang, B. L., Li, Y., Ding, Z. T., Jiang, Z. H., … Zhou, J. (2019). Synthesis and cytotoxicities of novel podophyllotoxin xyloside derivatives. Natural Product Communications, 14(7). https://doi.org/10.1177/1934578X19860668
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