Epidemiology and clinical manifestations of langerhans cell histiocytosis in children

Abstract

This chapter recounts the history of classification of LCH, the association with certain risk factors and with other malignancies, and the patterns of disease reported. In it, the history of LCH as a disease is told, from classification as three different diseases to unification as a single disease with a variable presentation. The chapter goes into further detail about the variety of different manifestations in different organ systems and assesses the evidence for suspected risk factors to LCH.