The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system. [Figure not available: see fulltext.].
CITATION STYLE
Szeto, J., Vu, V. A., Malerich, J. P., & Collins, N. (2019). Multi-step continuous flow synthesis of fluconazole. Journal of Flow Chemistry, 9(1), 35–42. https://doi.org/10.1007/s41981-018-0019-0
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