Propagation Model of Molecular Communication Based Targeted Drug Delivery for Atherosclerosis Disease Therapy

Abstract

Atherosclerosis is one of the major cardiovascular disorder which causes severe health issues in human body. It also ends with patient death, when improper therapy takes place. Conventional therapy measures includes oral statin therapy, skin mode application, Inhalation mode of therapy etc., has their own advantages. But they cannot fully exploit the inflammation because of lower systemic bioavailability. Nowadays, Nano molecular communication provides numerous solutions in the field of targeted drug delivery system. The aim of this article is to propose a new analytical model for the propagation process of molecules based on Brownian motion mechanism by formulating the probability density of the Latency in blood medium. This model is analyzed based on crucial parameters such as radius of the propagating molecules, blood viscosity, drift velocity, distance between Nano-Tx and Nano-Rx, temperature of the fluid medium with respect to various blood shear rates. Based on simulation results, the latency is highly affected with molecular radius, distance temperature, shear rate and drift velocity. Our future work is to apply this model for various drug carrying molecules used in the treatment of the cardiovascular diseases and to assess its propagation capacity under various conditions of blood medium.