The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer

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Abstract

Apoptosis is a coordinated cellular process that occurs in several physiological situations. Dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms. Lung cancer is among neoplastic conditions in which the role of non-coding RNAs in the regulation of apoptosis has been investigated. Non-coding RNAs that regulate apoptosis in lung cancer have functional interactions with PI3K/Akt, PTEN, GSK-3β, NF-κB, Bcl-2, Bax, p53, mTOR and other important cancer-related pathways. Globally, over-expression of apoptosis-blocking non-coding RNAs has been associated with poor prognosis of patients, while apoptosis-promoting ones have the opposite effect. In the current paper, we describe the impact of lncRNAs and miRNAs on cell apoptosis in lung cancer.

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Ghafouri-Fard, S., Aghabalazade, A., Shoorei, H., Majidpoor, J., Taheri, M., & Mokhtari, M. (2021, July 21). The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer. Frontiers in Oncology. Frontiers Media S.A. https://doi.org/10.3389/fonc.2021.714795

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