Evaluation of antipyretic and anti-inflammatory activity of Aqueous Extract of Leptadenia Reticulata in animal models

Abstract

Objective: To study the antipyretic and anti-inflammatory effects of the Aqueous Extract of Leptadenia Reticulata (AELR) in different animal models. Materials and Methods: Acute toxicity studies were performed and extract was found to be safe upto 2000 mg/kg. Two doses were selected for the “evaluation of antipyretic and anti-inflammatory activity of aqueous extract of Leptadenia reticulata in animal models” i.e 200 mg/kg and 400 mg/kg b. w. Antipyretic activity was evaluated using baker’s yeast induced pyrexia in albino rats and cow milk induced pyrexia in albino rabbits. Anti-inflammatory activity was evaluated using carrageenan induced paw edema and turpentine oil induced paw edema in albino rats. Results: In all the animal models AELR at the dose of 200 mg/kg b.w and 400 mg/kg b.w showed significant (P<0.01) antipyretic and anti-inflammatory activity. Conclusion: These finding could justify the inclusion of aqueous extract of Leptadenia reticulata in the management of pyrexia and inflammation.