Voltammetric determination of gabapentin by a carbon ceramic electrode modified with multiwalled carbon nanotubes and nickel-catechol complex

Abstract

Sol-gel technique was used for the fabrication of a renewable carbon ceramic electrode (CCE) modified with nickel-catechol complex (Ni-CA). The complex was deposited on the surface of a multiwalled carbon nanotubes-CCE by potential cycling in the range of 0.0-0.8 V (vs. saturated calomel electrode, SCE). Ni-CA showed electrocatalytic activity towards the redox reaction of gabapentin. A linear relationship of anodic peak current with gabapentin concentration was observed in a range of 1.25-63.23 μmol L-1 with a limit of detection of 0.5 μmol L-1. The electrode response towards gabapentin was quite reproducible and a long-term stability of the electrode (more than 2 months) was observed. The electrode was successfully applied to the determination of gabapentin in pharmaceutical preparations.