Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy

Abstract

Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented with hypoglycaemic coma. These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent. The mechanism of this cholestasis is not clear at present. © 1981 The Fellowship of Postgraduate Medicine.