Abstract
A multiple response: YbIII-HPDO3A has been used for the development of a magnetic resonance imaging method that is able to assess pH value and temperature simultaneously, irrespective of the concentration of the complex (see graph). This contrast agent has potential in a clinical setting as it shows the same stability and invivo pharmacokinetic properties as Gd III-HPDO3A, which is already used in clinical practices under the trade name of ProHance. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Dellicastelli, D., Terreno, E., & Aime, S. (2011). YbIII-HPDO3A: A dual pH- and temperature-responsive CEST agent. Angewandte Chemie - International Edition, 50(8), 1798–1800. https://doi.org/10.1002/anie.201007105
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