The blood-brain barrier of the neurovascular unit is a critical organ for normal brain function. It is continuously exposed to mechanical stress both from the peripheral circulation and plasma osmolarity changes. Barrier integrity is regulated by a number of mechanisms, including influx of calcium ions and activation of calcium-sensitive signaling pathways. This review addresses the molecular identity of the channels underlying mechanosensitive calcium influx, and hypothesizes a central role for transient receptor potential channels in mechanosensitive regulation of blood-brain barrier endothelial cell function.
CITATION STYLE
Brown, R. C., & O’Neil, R. G. (2008). Mechanosensitive Calcium Fluxes in the Neurovascular Unit: TRP Channel Regulation of the Blood-Brain Barrier. In Mechanosensitivity of the Nervous System (pp. 321–343). Springer Netherlands. https://doi.org/10.1007/978-1-4020-8716-5_15
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