Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature

14Citations
Citations of this article
53Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

BackgroundChildhood obesity is associated with elevated blood concentrations of inflammation markers. It is not known to what extent inflammation precedes the development of obesity.MethodsIn a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age.ResultsAmong children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14. Among children delivered for maternal or fetal indications (n=148), obesity was associated with elevated concentrations of seven proteins on the 14th postnatal day. In multivariable models in the spontaneous indications subsample, elevated IL-6 on day 1 predicted obesity (odds ratio: 2.9; 95% confidence limits: 1.2, 6.8), whereas elevated VCAM-1 on day 14 predicted overweight at 2 years of age (odds ratio: 2.3; 95% confidence limits: 1.2, 4.3).ConclusionsIn this cohort, neonatal systemic inflammation preceded the onset of obesity, suggesting that inflammation might contribute to the development of obesity.

References Powered by Scopus

Cardiometabolic risks and severity of obesity in children and young adults

725Citations
N/AReaders
Get full text

Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

706Citations
N/AReaders
Get full text

Chronic and degenerative diseases: Obesity, inflammation and the immune system

605Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Immunoendocrine dysregulation during gestational diabetes mellitus: The central role of the placenta

43Citations
N/AReaders
Get full text

Antecedents of obesity among children born extremely preterm

28Citations
N/AReaders
Get full text

Gestational sleep deprivation is associated with higher offspring body mass index and blood pressure

17Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Perrin, E. M., O’Shea, T. M., Skinner, A. C., Bose, C., Allred, E. N., Fichorova, R. N., … Leviton, A. (2018). Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. Pediatric Research, 83(6), 1110–1119. https://doi.org/10.1038/pr.2017.313

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

50%

Researcher 7

32%

Professor / Associate Prof. 4

18%

Readers' Discipline

Tooltip

Medicine and Dentistry 11

58%

Nursing and Health Professions 4

21%

Social Sciences 2

11%

Psychology 2

11%

Save time finding and organizing research with Mendeley

Sign up for free