On the adhesion of vesicles by cell adhesion molecules

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This paper gives a detailed analysis of experiments on the kinetics of aggregation of lipid vesicles containing neural cell adhesion molecules (N-CAM). An explanation for the dependence of the "initial aggregation rate," kagg, on the square of the vesicle concentration is given, accounting both for Brownian motion of the vesicles and shear effects. A model in which trimers of N-CAM are one-half of the molecular unit bridging two vesicles explains the observed dependence of kagg on up to the sixth power of the lateral N-CAM concentration and corroborates electron micrographic evidence for N-CAM "triskelions." © 1985, The Biophysical Society. All rights reserved.




Bell, G. I., & Torney, D. C. (1985). On the adhesion of vesicles by cell adhesion molecules. Biophysical Journal, 48(6), 939–947. https://doi.org/10.1016/S0006-3495(85)83857-1

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