P603 Hospitalisation risk and reintervention after ileocolonic resection with anastomosis in patients with Crohn's disease. Results from the PRACTICROHN study

Abstract

Background: 25% to 61% of patients with Crohn's disease (CD) will require intestinal resection during the first 5 years after diagnosis. In the follow-up can develop complications and require hospitalisation or new surgeries. The aim of this study was to determine the incidence of hospitalisations and reinterventions in patients with CD undergoing ileocolonic resection. Method(s): PRACTICROHN was a retrospective study, including pa-tients with CD aged >=18 years-old from 26 centres who underwent surgical resection with ileocolonic or ileorectal anastomosis between January 2007 and December 2010. Clinical data after surgery were retrospectively collected from medical records. Result(s): 314 patients were analyzed (mean age 40 years [SD 13], 48% men). From 115 patients (36%) that were smokers at surgery only 30 (26%) quitted smoking during the first and second year after surgery, and 40 (34%) at 5 year follow-up. Median time from CD diagnosis to surgery was 6 years (IQR 1-12). Indication for surgery was: 147 (48%) structuring disease, 98 (32%) penetrating disease, 46 (15%) stricturing + penetrating and 14 (4%) refractoriness to medical treatment. 208 (68%) of patients received preventive therapy after surgery: 13% aminosalycilates, 9% antibiotics, 46% im-munomodulators (IMM) and 1% anti-TNFs. During follow-up, 56 (18%) patients required at least one hospitalisation during the first year with a median stay of 10 days (IQR 6-15). The reasons for hos-pitalisation were: 36 (45%) for CD recurrence or active disease and 35 (44%) from surgical-related complications, 1 (1%) for infection and 7 (9%) for other reasons. At 5 years, 94 (30%) patients had re-quired hospitalisation, mostly for recurrent active disease. 45 (14%) patients required reoperation within 5 years, with 23/45 (51%) during the first year, and the most common reason was surgical complications. (18/45, 40%). The median time to first reoperation was 228 days (IQR 133-527). At year 5, 22 patients needed reoperation due to CD activity, the most common reason was fistulae (11/22, 50%). No differences in the 5-year surgical recurrence were found in those with or without prophylaxis (Table 1). Conclusion(s): During the CD related post-surgery evolution, around 20% of the patients will require hospitalisation for postoperative complications during the first year and 30% will require hospitalisa-tion at 5 years follow-up due to disease recurrence. 14% will require a new reintervention after 5 years.