Enhanced accumulation of LDLs within the venous graft wall may account for its accelerated atherogenesis

Abstract

To test the hypothesis that the venous graft when implanted in an arterial bypass might endure a fast infiltra-tion/accumulation of low-density lipoproteins (LDLs) within the vessel and hence the accelerated atherogenesis. we meas-ured measured DiI-LDLs uptake by both arteries and veins under arterial condition. The experimental results showed that that the amount of DiI-LDLs uptake by the venous wall was much higher compared with arterial wall, which was con-sistent with our hypothesis.*.