Clinical, Hematological and Inflammatory Markers Profile in COVID-19 Patients at Tertiary Care Centre

Abstract

Background: The ongoing pandemic of severe acute respiratory syndrome by coronavirus-2 (SARS-CoV-2) continues to pose several diagnostic and therapeutic challenges. Assessing clinical, demographic, biochemical, haematological and inflammatory parameters have thus become important for investigating the COVID-19 cases. Materials and Methods: A total of 505 Covid-19 positive cases were included in this study to compare their haematological, biochemical and inflammatory parameters among mild, moderate and severe cases who were categorized as per ICMR guidelines and Institute guidelines. Results: In our study 54% patients belonged to >50 years of age group. Different Haematological values were studied for statistical significance where White blood cell count (WBC), Neutrophil count, Neutrophil lymphocyte ratio (NLR), Absolute neutrophil count (ANC), Lymphocyte count and Absolute lymphocyte count (ALC) showed statistical significance with p value <0.05. Among inflammatory markers C-reactive protein (CRP), coagulative marker D-Dimer and biochemical parameters such as S.Ferritin and lactate dehydrogenase (LDH) levels showed statistical significance with p value <0.05.There was no significant change in the Hemoglobin, Monocyte, Absolute monocyte count (AMC), Lymphocyte monocyte ratio (LMR) and platelet count. Conclusion: According to the findings of our study, WBC, neutrophil, lymphocyte, neutrophil lymphocyte ratio, CRP, D-dimer, LDH and serum ferritin played an essential part in risk stratification models that serves as clinical predictors of severity in COVID-19 patients.