Anti-Inflammatory Constituents Of Topically Applied Crude Drugs. V.1) Constituents And Anti-Inflammatory Effect Of Aoki, Aucuba Japonica Thunb

Abstract

The Et20-soluble fraction of the MeOH extract of the leaves of Aucuba japonica Thunb. showed an anti-inflammatory effect when topically applied to rats.E-Phytol, phytone, bis(2-ethylhexyl)phthalate and friedelin were isolated as active anti-inflammatory components inhibiting carrageenin-induced paw edema. The most effective, E-phytol inhibited histamine-induced paw edema more potently than the compound 48/80-induced edema, suggesting that the mechanism of action is due to inhibition of the H1 receptor. © 1994, The Pharmaceutical Society of Japan. All rights reserved.