The striatum is the main input structure of the basal ganglia. It is a centrally located region where afferents from the cerebral cortex, thalamus, and substantia nigra converge and interact. Glutamate is released from cortical and, to a lesser extent, thalamic terminals (1,2). Dopamine (DA) is released from nigrostriatal terminals (3). Because glutamate and DA inputs terminate on the same spines of striatal medium-sized spiny neurons (MSSNs), these sites offer the potential for physiological interactions between the glutamate and DA transmitter systems (4). © 2005 Humana Press.
CITATION STYLE
Cepeda, C., Ariano, M. A., & Levine, M. S. (2005). Dopamine and glutamate in huntington’s disease. In Dopamine and Glutamate in Psychiatric Disorders (pp. 539–565). Humana Press. https://doi.org/10.1007/978-1-59259-852-6_23
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