Efficient enzymatic amine resolution at high substrate input using diethyl malonate as an acyl donor of low hazard potential

Abstract

Diethyl malonate turned out to be both a "green" and highly efficient acyl donor in the lipase-catalyzed resolution of amines, thus representing an attractive alternative to currently applied acyl donors. By means of this acyl donor a highly efficient enzymatic process for the resolution of amines, running at high substrate input of up to 200 g/L in an organic solvent classified as "usable" according to the Pfizer Solvent Selection Guide, is presented. © 2012 Verlag der Zeitschrift fur Naturforschung.