Phase Transfer Catalysis of Henry and Darzens Reactions

Abstract

We describe in this work the influence of the addition of phase transfer catalyst in heterogeneous medium liquid/liquid on the output of the reactions of Darzens and Henry. It proves that the reaction of Darzens is favoured in the presence of low base such as K 2 CO 3 and Et 3 N. Phase transfer catalysis is an efficient activa-tion method in Darzens and Henry reactions. Thus, the Ethylene Diammonium Diacetate (EDD) has a com-parable catalytic activity has that of quaternary ammonium salts in the reaction of Darzens.