Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

Abstract

Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective. © 2005 by the Infectious Diseases Society of America. All rights reserved.