Diagnostic and prognostic value of galectin-3, serum creatinine, and cystatin C in chronic kidney diseases

Abstract

Objectives: This study was undertaken to determine the diagnostic and prognostic values of galectin-3 (Gal-3) in patients with chronic kidney disease (CKD). Methods: Patients with CKD (n=150) were enrolled as the CKD group, which was divided into six groups according to glomerular filtration rates (GFR) indexes. At the same time, 50 healthy adults were chosen for the control group (NC). Measured data included the levels of serum Gal-3, serum creatinine (SCr), β2-microglobulin (β2-MG), 24-hour urinary protein, cystatin C (CysC), serum albumin (Alb) and other related indicators. Results: There was no significant difference between CKD and NC group in age, gender and the level of Alb. CKD group had lower estimated glomerular filtration rate (eGFR) but higher Gal-3, CysC, SCr, β2MG and 24-hour urinary protein excretion than control group (P