Hyperprolactinemia and Pituitary Causes of Amenorrhea

Abstract

Pituitary causes of amenorrhea constitute approximately 18% of cases of secondary amenorrhea but only approximately 7% of cases of primary amenorrhea [1]. The most common pituitary cause of amenorrhea is hyperprolactinemia constituting 80% of all pituitary causes of secondary amenorrhea and approximately 15% of cases of secondary amenorrhea due to any cause [2]. In this chapter, we review the causes, clinical presentation, diagnostic evaluation, and current treatment strategies for amenorrhea due to hyperprolactinemia and other pituitary disorders. We present an illustrative case of secondary amenorrhea due to a pituitary cause.