A personalized biomechanical model for respiratory motion prediction

12Citations
Citations of this article
38Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Time-resolved imaging of the thorax or abdominal area is affected by respiratory motion. Nowadays, one-dimensional respiratory surrogates are used to estimate the current state of the lung during its cycle, but with rather poor results. This paper presents a framework to predict the 3D lung motion based on a patient-specific finite element model of respiratory mechanics estimated from two CT images at end of inspiration (EI) and end of expiration (EE). We first segment the lung, thorax and sub-diaphragm organs automatically using a machine-learning algorithm. Then, a biomechanical model of the lung, thorax and sub-diaphragm is employed to compute the 3D respiratory motion. Our model is driven by thoracic pressures, estimated automatically from the EE and EI images using a trust-region approach. Finally, lung motion is predicted by modulating the thoracic pressures. The effectiveness of our approach is evaluated by predicting lung deformation during exhale on five DIR-Lab datasets. Several personalization strategies are tested, showing that an average error of 3.88 ± 1.54 mm in predicted landmark positions can be achieved. Since our approach is generative, it may constitute a 3D surrogate information for more accurate medical image reconstruction and patient respiratory analysis.

Cite

CITATION STYLE

APA

Fuerst, B., Mansi, T., Zhang, J., Khurd, P., Declerck, J., Boettger, T., … Kamen, A. (2012). A personalized biomechanical model for respiratory motion prediction. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 7512 LNCS, pp. 566–573). Springer Verlag. https://doi.org/10.1007/978-3-642-33454-2_70

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free