Economical yet informative sequencing strategy

Abstract

Pasaniuc et al. simulated DNA sequencing on 1000 Genomes Project data sets at different depths to determine whether low-depth sequencing could be an accurate and cost-effective alternative to array-based SNP genotyping in genome-wide association studies. They found that low-depth sequencing (at 0.1–0.5×) has comparable accuracy to high-resolution SNP arrays — a result confirmed by real low-depth exome sequencing data.