Background: The human papillomavirus (HPV) prevalence in males has been reported to be between 3.6% and 84%, depending specially on the socioeconomic status. HPV infection has been related as a risk factor for penile cancer. This is a rare tumor, and other risk factors include lack of personal hygiene and men who have not undergone circumcision. Penile cancer is less than 1% of cancers in men in the United States, however, is much more common in some parts of Asia, Africa, and South America, where it accounts for up to 10% of cancers in men. This study aimed to determine the prevalence of HPV-DNA in penile cancers in São Luís, Brazil and to correlate the virus presence to histopathological factors. Methods: Tumor paraffin samples of 76 patients with penile carcinoma were tested in order to establish the prevalence and distribution of genotypic HPV using PCR/Nested and automated sequencing. To evaluate the association between HPV types and other clinical and morphological variables, a nonparametric ANOVA was performed using a Kruskal Wallis test, and statistical significance was determined to a value of p∈
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De Sousa, I. D. B., Vidal, F. C. B., Branco Vidal, J. P. C., De Mello, G. C. F., Do Desterro Soares Brandão Nascimento, M., & Brito, L. M. O. (2015). Prevalence of human papillomavirus in penile malignant tumors: Viral genotyping and clinical aspects. BMC Urology, 15(1). https://doi.org/10.1186/s12894-015-0007-8
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