Fermentation, isolation and characterization of antibiotic PR-1350

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Abstract

A number of strains of Oidiodendron truncatum was shown to produce a new antibiotic, PR-1350, which was isolated in the form of an amorphous powder either directly or via a crystalline monomethanolate, PR-1381, which in solution is reconverted to the parent compound. The antibiotic inhibits a broad spectrum of Gram-positive and Gram-negative bacteria in vitro, and has been shown to be active against P-388 lymphocytic leukemia in mice. Biosynthetic considerations based on the results of [l-I3C]acetate incorporation indicate that the antibiotic is a diterpene of the clerodane type. © 1983, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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Andersen, N. R., Otto, H., Lorck, B., & Rasmussen, P. R. (1983). Fermentation, isolation and characterization of antibiotic PR-1350. Journal of Antibiotics, 36(7), 753–760. https://doi.org/10.7164/antibiotics.36.753

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