Comparative genomics considers the detection of similarities and differences between extant genomes, and, based on more or less formalized hypotheses regarding the involved evolutionary processes, inferring ancestral states explaining the similarities and an evolutionary history explaining the differences. In this chapter, we focus on the reconstruction of the organization of ancient genomes into chromosomes. We review different methodological approaches and software, applied to a wide range of datasets from different kingdoms of life and at different evolutionary depths. We discuss relations with genome assembly, and potential approaches to validate computational predictions on ancient genomes that are almost always only accessible through these predictions.
CITATION STYLE
Anselmetti, Y., Luhmann, N., Bérard, S., Tannier, E., & Chauve, C. (2018). Comparative methods for reconstructing ancient genome organization. In Methods in Molecular Biology (Vol. 1704, pp. 343–362). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7463-4_13
Mendeley helps you to discover research relevant for your work.