Analytical evaluation of four on-site oral fluid drug testing devices

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Abstract

The use of oral fluid (OF) as an alternative matrix for the detection of drugs of abuse has increased over the last decade, leading to the need for a rapid, simple, and reliable on-site OF testing device. Four on-site OF drug testing devices (Dräger DrugTest 5000, Cozart DDS, Mavand Rapid STAT, and Innovacon OrAlert) were evaluated on 408 volunteers at drug treatment centers. UPLC-MS-MS results were used as reference to determine sensitivity, specificity and accuracy for each device, applying Belgian legal confirmation cutoffs for benzoylecgonine, cocaine, and THC (10 ng/mL); morphine and 6-acetylmorphine (5 ng/mL); and amphetamine and 3,4-methylenedioxymethylamphetamine (25 ng/mL). Sensitivity for cocaine was 50%, 50%, 27%, and 11% for DrugTest, OrAlert, Rapid STAT, and DDS 806, respectively. For opiates, sensitivities were 84%, 73%, 77%, and 65%, respectively. For THC, the sensitivities were 81%, 23%, 43%, and 28%, respectively. For amphetamines, the sensitivities were 75%, 33%, 17%, and 67%, respectively. Specificity was >88% for opiates and THC, > 90% for amphetamines, and > 97% for cocaine. All tests showed good specificity. Drug Test had the highest sensitivity, although it was still low for some analytes. © The Author [2012]. Published by Oxford University Press. All rights reserved.

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APA

Vanstechelman, S., Isalberti, C., Van der Linden, T., Pil, K., Legrand, S. A., & Verstraete, A. G. (2012). Analytical evaluation of four on-site oral fluid drug testing devices. Journal of Analytical Toxicology, 36(2), 136–140. https://doi.org/10.1093/jat/bkr016

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