Antimycins A10-A16, seven new antimycin antibiotics produced by Streptomyces spp. SPA-10191 and SPA-8893

Abstract

Seven new antimycin antibiotics, named antimycins A10, A 11, A12, A13, A14, A15 and A16, were isolated from the fermentation broth of strains of Streptomyces spp. SPA-10191 and SPA-8893, along with known antimycins A 1, A2, A3 and A4. The structures of the new antimycins were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited antifungal activity against Candida utilis. © Japan Antibiotics Research Association.