An efficient and practical synthesis of dibenzo[d,f][1,3]-dioxepines from 2,2'-dihydroxybiphenyl with terminal alkynes catalyzed by lewis acid TiCl 4

Abstract

A synthetic strategy toward the cyclic addition of 2,2'-dihydroxybiphenyl to terminal alkynes has been developed using Lewis acid TiCl4 as catalyst. The reactions generated dibenzo[d,f][1,3]dioxepines derivatives in good yields with excellent regio-selectivity in the presence of catalytic amount of TiCl4 under mild reaction conditions. Copyright © 2011 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.