Facile and green synthesis of Hantzsch derivatives in deep eutectic solvent

Abstract

An efficient one-pot synthesis of polyhydroacridines and polyhydroquinolines through the Hantzsch reaction in deep eutectic solvent choline chloride/urea (1:2) has been developed. Good to excellent yields, broad substrate compatibility as well as the reusability of the solvent are the major advantages of the present protocol.