Renin release from ischemic kidneys following angiotensin infusion in dogs

Abstract

The study is concerned with renal release of renin responding to intravenous administration of synthetic angiotensin II-asp1-β-amide (Hypertensin, CIBA) in the dogs with acute renal ischemia produced by aortic clamping and those with chronic renal hypertension caused by main renal artery clamping. Contralateral kidney was removed in both types of the experiment. Renin release was not inhibited but rather augmented when small amount of angiotensin (0.2 ng/kg/min) was infused. The response was not observed in the denervated kidney with acute ischemia. In control dogs without renal ischemia renin release was suppressed with increasing amount of angiotensin administered. © 1969, The Japanese Circulation Society. All rights reserved.