Evaluation of potentiation effect of omega-3 fatty acid on the antidepressant efficacy of escitalopram in albino rats

Abstract

Depression is a common problem worldwide since the ages.Mostly it is treated with Selective serotonin reuptake inhibitors (SSRI) but they are not effective in each and every patient. Hence other methods for better effective ways to treat depression are needed. Our study thus aims at studying the potentiation effect of omega-3 fatty acid in combination with escitalopram for treatment of depression. Combination therapy also helps to reduce side effects of SSRIs and a lower dose can be used in children and pregnant mothers. Various animal models have been used in this pre-clinical study to study the effect of omega-3 fatty acids. Further clinical studies may be required to validate the results of this study.