Synthesis approaches to (-)-cytoxazone, a novel synthesis approaches to (-)-cytoxazone, a novel cytokine modulator, and related structures cytokine modulator, and related structures

Abstract

oxazolidin-2-one (-)-Cytoxazone, 4,5-disubstituted originally ring. isolated It is known from that cultures this natural of a Streptomyces product presents species a cytokine has an modulator oxazolidin-2-one effect through 4,5-disubstituted the signaling ring. pathway It is known of Th2 that cells this (type natural 2 cytokines), product presents which are a involved cytokine in modulator the process effect of through growth and the signaling differentiation pathway of cells. of Th2 From cells this, (type the 2 cytokines), interest in the which development are involved of research in the process aimed of at growth the total and synthesis differentiation of this molecule of cells. and Fromits this, analogs the interest has remained the development high, which can of be research confirmed aimedby atthe the large total synthesis number of of this publications moleculeon andthe itstopic, analogs more has than remained 30 to high, date. which This review can be focuses confirmed on by the the various large number creative of methods publications for the onsynthesis topic, of more (-)-cytoxazone than 30 date. and This its congeners. review focuses The assessment on the various of the creative preparation methodsof for this theoxazolidinone synthesis of (-)-cytoxazone and related structures and its congeners. serves as a The treatise assessment on the efforts of the preparation made in the ofsynthesis this oxazolidinone of this important and related class structures of compound serves as from a treatise its first ontotal the efforts synthesis made in 1999. in the synthesis of this important class of compound from its first total synthesis in 1999.