Liquid formulations

Abstract

Liquid formulations are a preferred or required oral dosage form for many in the pediatric age group. They require a stable, dissolved, or suspended form of the drug that meets release, bioavailability, and taste requirements. Both immediate and sustained release liquid products are possible. Liquid formulation strategies include direct incorporation of drug in a dissolved or suspended state, incorporation of drug in the form of a suspended drug:ion exchange resin complex , and incorporation of drug in the form of a dissolved or suspended drug:cyclodextrin inclusion complex . This chapter briefl y discusses pertinent history and application of these technologies in relation to oral liquid formulations for pediatric patients.