Poliovirus Antibody Response in Serum and Nasal Secretions Following Intranasal Inoculation with Inactivated Poliovaccine

Abstract

Secretory antibody response in nasal secretions has been studied following intranasal inoculation of large doses of inactivated poliovaccine. Secretory γA antibody appeared in the nasal secretions as early as 5 days after the first dose of a primary series of three intranasal doses of vaccine, and the antibody activity disappeared by 77 to 100 days. The response to a secondary intranasal inoculation of inactivated vaccine 3 to 4 months later, although shorter-lived, was generally similar to the primary response. There was no evidence of anamnesis. The secretory γA response appeared in the absence of any significant serum response. High titers of secretory antibody in nasal secretions seemed to depress nasopharyngeal replication of live attenuated virus administered orally, although no effect on virus replication in the lower alimentary tract was observed.