Direct blood pressure monitoring in laboratory rodents via implantable radio telemetry.

Abstract

The ability to monitor and record precise blood pressure fluctuations in research animals is vital to research for human hypertension. Direct measurement of blood pressure via implantable radio telemetry devices is the preferred method for automatic collection of chronic, continuous blood pressure data. Two surgical techniques are described for instrumenting the two most commonly used laboratory rodent species with radiotelemetry devices. The basic rat procedure involves advancing a blood pressure catheter into the abdominal aorta and placing a radio transmitting device in the peritoneal cavity. The mouse technique involves advancing a thin, flexible catheter from the left carotid artery into the aortic arch and placing the telemetry device under the skin along the animal's flank. Both procedures yield a chronically instrumented model to provide accurate blood pressure data from an unrestrained animal in its home cage.