Abstract
In nuclear medicine, simultaneous dual-isotope imaging is used to determine the distribution of two radiotracers from a single acquisition and for emission/transmission (E/T) imaging in SPECT. However, no general solution to the cross-talk problem caused by scattered and unscattered photons has been found yet and accurate quantification cannot be performed. We describe a general method of spectral factor analysis (SFA) for multi-isotope acquisitions. SFA corrects for cross-talk due to unscattered and scattered photons in planar or SPECT imaging involving two or more radiotracers and for E/T scans. A Tc-99m/I-123 phantom study shows that quantitative accuracy is within 10% with SFA, while errors up to 170% are observed using conventional spectral windows.
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CITATION STYLE
Buvat, I., Hapdey, S., Benali, H., Todd-Pokropek, A., & Di Paola, R. (1999). Spectral factor analysis for multi-isotope imaging in nuclear medicine. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 1613, pp. 442–447). Springer Verlag. https://doi.org/10.1007/3-540-48714-x_43
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