McCune Albright syndrome

Abstract

Precocious puberty, presenting as premature thelarche or menarche in girls, as early as 2-3 years in association with polyostotic fibrous dysplasia, cafe-au-lait spots and other endocrinopathies should suggest the possibility of McCune Albright Syndrome (MAS). The precocious puberty associated with MAS typically is gonadotrophin independent. Fractures, malignancies and endocrine disorders are the modalities associated with this syndrome.