Anti-inflammatory activity of Sabicea brevipes Wernharm (Rubiaceae)

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Abstract

Over the years, medicinal plants have been employed in the treatment of inflammation and related ailments. This study evaluated the anti-inflammatory potential of the aerial parts of S. brevipes. The extracts and fractions were further evaluated for anti-inflammatory activity in carrageenan-induced rat model at varying doses (200 and 400 mg/kg doses, orally) for 5 h of treatment. The result of the phytochemical screening showed the presence of alkaloids, terpenoids, glycosides, flavonoids and tannins in the aerial parts of the plant. The in vivo anti-inflammatory study exhibited inhibition of 42% and 44%, 47% and 36%, 33% and 31%, and 43% and 42% for methanol extract n-hexane fraction, ethyl acetate fraction, and methanol fraction, at 200 and 400 mg/kg doses, respectively. The positive control (diclofenac sodium) showed an inhibition value of 51% at 5 mg/kg dose. Finally, it is concluded that S. brevipes possesses anti-inflammatory potential which validates the enthnomedicinal claim of the plant.

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Attah, E. I., Ugwuagbo, S. C., Chinnam, S., Eze, F. I., Nnadi, C. O., Agbo, M. O., … Jagtap, M. R. (2022). Anti-inflammatory activity of Sabicea brevipes Wernharm (Rubiaceae). Pharmacia, 69(2), 311–317. https://doi.org/10.3897/pharmacia.69.e82311

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