Direct evidence that the FimH protein is the mannose-specific adhesion of Escherichia coli type 1 fimbriae

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Abstract

Type 1 fimbriae of Escherichia coli are surface organelles which mediate binding to D-mannose-containing structures. By direct binding of FimH to D-mannose attached to a carrier protein, we demonstrated that this protein was uniquely responsible for the receptor specificity. Furthermore, we show by the receptor immuno-electron microscopy that the FimH protein is located laterally in the structure of the type 1 fimbriae.

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Krogfelt, K. A., Bergmans, H., & Klemm, P. (1990). Direct evidence that the FimH protein is the mannose-specific adhesion of Escherichia coli type 1 fimbriae. Infection and Immunity, 58(6), 1995–1998. https://doi.org/10.1128/iai.58.6.1995-1998.1990

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