Biodegradation and biotransformation of polycyclic non-steroidal anti-inflammatory drugs

68Citations
Citations of this article
131Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

In recent years the increased use of polycyclic non-steroidal anti-inflammatory drugs has resulted in their presence in the environment. This in turn may cause potential negative effects on living organisms. While the biotransformation mechanisms of polycyclic non-steroidal anti-inflammatory drugs in the human body and in other mammals have been extensively studied, degradation of these drugs by microorganisms has seldom been investigated and is largely unknown. Biotransformation/biodegradation of polycyclic non-steroidal anti-inflammatory drugs is caused by fungal microorganisms, mainly white-rot fungi, and a few strains of bacteria. However, hitherto only complete degradation of olsazine was described. The first step of the transformation is most often hydroxylation catalyzed by cytochrom P-450 monooxygenases, or oxygenation by laccases and three peroxidases: lignin peroxidase, manganese-dependent peroxidase and versatile peroxidase manganese-dependent peroxidase. The aim of this work is to summarize the knowledge about the biotransformation and/or biodegradation of polycyclic non-steroidal anti-inflammatory drugs and to present their biotransformation pathways.

Cite

CITATION STYLE

APA

Domaradzka, D., Guzik, U., & Wojcieszyńska, D. (2015, June 15). Biodegradation and biotransformation of polycyclic non-steroidal anti-inflammatory drugs. Reviews in Environmental Science and Biotechnology. Kluwer Academic Publishers. https://doi.org/10.1007/s11157-015-9364-8

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free