Multi-modal mass spectrometric imaging of uveal melanoma

3Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

Matrix assisted laser desorption ionisation mass spectrometry imaging (MALDI-MSI), was used to obtain images of lipids and metabolite distribution in formalin fixed and embedded in paraffin (FFPE)whole eye sections containing primary uveal melanomas (UM). Using this technique, it was possible to obtain images of lysophosphatidylcholine (LPC) type lipid distribution that highlighted the tumour regions. Laser ablation inductively coupled plasma mass spectrometry images (LA-ICP-MS) performed on UM sections showed increases in copper within the tumour periphery and intratumoural zinc in tissue from patients with poor prognosis. These preliminary data indicate that multi-modal MSI has the potential to provide insights into the role of trace metals and cancer metastasis.

Cite

CITATION STYLE

APA

Cole, L. M., Handley, J., Claude, E., Duckett, C. J., Mudhar, H. S., Sisley, K., & Clench, M. R. (2021). Multi-modal mass spectrometric imaging of uveal melanoma. Metabolites, 11(8). https://doi.org/10.3390/metabo11080560

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free