Hemogasometry, metabolic profile and acute-phase proteins in primiparous Holstein cows supplemented with butafosfana associated or not of cyanocobalamin

Abstract

The aim of study was to evaluate whether butafosfan, associated or not with cyanocobalamin, alters the metabolic profile, hemogasometrics and acute phase proteins in recent postpartum dairy cows. Twenty-five cows (n = 25) were selected for study and divided into three groups: Butafosfan (BUT, n = 9); Butafosfan + Cyanocobalamin (BUTC, n = 9); and Control (CTL, n = 7). Treatments were applied daily from calving until 5 days postpartum. Blood samples for hemogasometry were performed on days 0, 1, 2 and 3, and for other metabolites on days 0, 1, 2, 3, 4, 5, 10, 15, 20 and 28 postpartum. Blood pH was lower in the BUT and BUTC groups than in the CTL group (p =.03) and carbon dioxide pressure was higher in the BUT and BUTC groups compared to CTL (p =.01). In addition, ionised calcium levels were higher in the BUT and BUTC groups (p =.0003) in comparison to CTL, whereas the BUT group had higher levels. The BUT group had the lowest levels of paraoxonase (p =.03). On the other hand, glucose levels tended to be highest in the BUT group (p =.08). The butafosfan with or without cyanocobalamin increased ionised calcium levels and tended to stabilise blood pH in the early post-partum cows, and butafosfan without cyanocobalamin tended to increase blood glucose levels.Highlights Treated animals increase serum ionised calcium; Treated animals have a reduction in blood pH; Butafosfan tends to increase the glucose concentration.