Mitochondria-targeted plastoquinone antioxidant SkQR1 decreases trauma-induced neurological deficit in rat

Abstract

A protective effect of a mitochondria-targeted antioxidant, a cationic rhodamine derivative linked to a plasto-quinone molecule (10-(6'-plastoquinonyl) decylrhodamine-19, SkQR1) was studied in the model of open focal trauma of rat brain sensorimotor cortex. It was found that daily intraperitoneal injections of SkQR1 (100 nmol/kg) for 4 days after the trauma improved performance in a test characterizing neurological deficit and decreased the volume of the damaged corti-cal area. Our results suggest that SkQR1 exhibits profound neuroprotective effect, which may be explained by its antioxida-tive activity. © Pleiades Publishing, Ltd., 2012.