A new boronic acid-based fluorescent sensor for L-dihydroxy-phenylalanine

Abstract

Catecholamines, such as dopamine and l-dihydroxyphenylalanine (l-DOPA), are associated with different physiological functions and diseases. In our recent studies, a novel water-soluble boronic acid compound 3c was identified as a selective fluorescent sensor for l-DOPA. This compound not only has the ability to interact with dopamine and catechol, but also has no fluorescence intensity change for l-DOPA precursors in vivo, such as l-tyrosine. © 2012, International Research and Cooperation Association for Bio & Socio-Sciences Advancement. All rights reserved.